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Commonly in liquid form and available in various chemical compositions, solvents are substances that dissolve solutes to form solutions. The amount and type of solute that a solvent can dissolve is dependent upon temperature and polarity.
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Zotizalkib is a potent, selective, CNS-penetrant, and orally active inhibitor of wild-type ALK and ALK-resistant mutations, such as G1202R and L1196M. It demonstrates strong antitumor activities and is for research use only.
Potent, selective, CNS-penetrant, and orally active inhibitor
Inhibits wild-type ALK and ALK-resistant mutations
Demonstrates strong antitumor activities
For research use only
Purity: 98.0%
Molecular weight: 447.41
CAS number: 2648641-36-3
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(R)-(-)-2-Butanol is the R enantiomer of 2-butanol supplied as a 10 mM solution in DMSO (1 mL vial) and as bulk liquid; it is used as a chemical intermediate and reagent in synthesis and research applications.
R enantiomer of 2-butanol.
CAS number 14898-79-4.
Purity 99.98% as reported by manufacturer.
Molecular formula C4H10O; molecular weight 74.12 g/mol.
Supplied as 10 mM solution in DMSO (1 mL) and in bulk liquid sizes (1 g, 5 g, 10 g, 50 g).
Manufacturer notes DMSO solubility ~100 mg/mL; ultrasonic may be needed and use newly opened DMSO due to hygroscopicity.
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Zotizalkib (TPX-0131) is a potent, CNS-penetrant, orally active inhibitor of anaplastic lymphoma kinase (ALK) designed for research use. It demonstrates low-nanomolar activity against wild-type ALK and a broad spectrum of resistance mutations and has shown antitumor effects in preclinical studies.
Potent ALK inhibition (IC50 ≈ 1.4 nM).
CNS-penetrant, supporting brain exposure in preclinical models.
Active against multiple ALK resistance mutations.
High chemical purity (~98.0%).
Chemical formula C21H20F3N5O3 and molecular weight 447.41 g/mol.
Supplied for research use only; not for human or clinical use.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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A synthetic estrogen; stimulates proliferation of estrogen-dependent MCF-7 breast cancer cells in vitro from 0.16-20 μM; lacks ER binding activity (IC50s = >100 μM for ERα and ERβ); has been used in the synthesis of various estrogen receptor modulators
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A synthetic estrogen; stimulates proliferation of estrogen-dependent MCF-7 breast cancer cells in vitro from 0.16-20 μM; lacks ER binding activity (IC50s = >100 μM for ERα and ERβ); has been used in the synthesis of various estrogen receptor modulators
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More